Nadaf, Afra Quasar A. published the artcileDesign, synthesis and biological evaluation of novel N,4-diphenylthiazol-2-amine derivatives, Computed Properties of 3696-23-9, the publication is Medicinal Chemistry Research (2020), 29(3), 442-458, database is CAplus.
Novel N,4-diphenylthiazol-2-amine derivatives I (R1 = Cl, OMe; R2 = Br, NO2; R3 = Et, i-Pr, n-Pr, s-Bu, octan-3-yl) were designed and synthesized employing Hantzsch method. The three-step reaction involved in the synthesis occurred at a faster rate with excellent yields in eco-friendly conditions. Single-crystal X-ray diffraction studies also confirmed the formation of title compds I. These compounds I were evaluated in vitro for their antimicrobial and anti-inflammatory activities. The results demonstrated that most of the tested compounds I showed potent antifungal activity. Interestingly, these compounds I also exhibited good anti-inflammatory and moderate antibacterial activity towards sensitive as well as resistant bacterial strains. In silico studies depicted their good binding affinity profile against S. aureus (PDB ID: 1AD4) and C. albicans (PDB ID: 1AI9).
Medicinal Chemistry Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.
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