Zhao, Guofeng published the artcileDevelopment of a displacer-immobilized ligand docking scheme for displacer screening for protein displacement chromatography, Synthetic Route of 23616-79-7, the publication is Biochemical Engineering Journal (2011), 55(1), 32-42, database is CAplus.
Displacement chromatog. is a powerful technique for protein purification, but the availability of high-efficacy displacers has greatly limited its applications. In this work, a displacer-immobilized ligand docking scheme was developed for the prediction of displacer efficacy and displacer screening for displacement chromatog. of proteins. The structure of immobilized ligand was established by coupling a certain number of ligands to the 3D structure of agarose. A number of known cation, anion and hydrophobic displacers were docked to their resp. immobilized ligands to verify the effectiveness of the scheme, and the Spearman ranking correlation coefficients of all cases were over 0.5. The scheme was then used to screen displacers for hydrophobic charge induction chromatog. from over 1800 com. available compounds Column displacement experiments of several representative compounds showed that the identified displacers were efficacious in the displacement of single component and binary mixtures It is expected that the combination of the docking scheme with the existing techniques for displacer discovery/design would greatly facilitate the discovery of high-affinity displacers for protein purification
Biochemical Engineering Journal published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C14H22O2, Synthetic Route of 23616-79-7.
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