Adding a certain compound to certain chemical reactions, such as: 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4584-46-7, Product Details of 4584-46-7
To a solution of 4-hydroxy-3-methoxybenzaldehyde (10g) in DMF (500ml) were added potassium carbonate (18.20g)and 2-chloro-N,N-dimethylethylamine hydrochloride (14.08g). The reaction mixture was stirred at 80C for 1 h30min. The suspension was filtrated off and the filtrate was diluted with Et20 and sat. aq. NaCI. The aq. layer was extracted with Et20, the combined org. layers were dried over MgS04, filtrated off and evaporated in vacuo. The crude was purified by CC (Buchi Sepacore, 70g cartridge, solvent A: DCM, solvent B: MeOH, gradient in %B: 2 to 4, flow rate: 20ml/min) to afford 7.3g of a yellow oil. LC-MS (A): tR = 0.60min; [M+H]+: 224.48.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; KIMMERLIN, Thierry; REMEN, Lubos; SIENDT, Herve; VERCAUTEREN, Magali; WELFORD, Richard; (138 pag.)WO2016/177690; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics