Crombie, Aimee L.’s team published research in Bioorganic & Medicinal Chemistry Letters in 20 | CAS: 209919-30-2

Bioorganic & Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Quality Control of 209919-30-2.

Crombie, Aimee L. published the artcileSynthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists, Quality Control of 209919-30-2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(12), 3742-3745, database is CAplus and MEDLINE.

A series of biaryl amides containing an azabicyclooctane amine headpiece were synthesized and evaluated as mixed arginine vasopressin (AVP) receptor antagonists. Several analogs, including I (Ar = 2-Me-C6H4, 3-AcHN-C6H4, benzothiophen-3-yl, naphthalen-1-yl), were shown to have excellent V1a– and good V2-receptor binding affinities. Compound I (Ar = benzothiophen-3-yl) was further profiled for drug-like properties and for an in vitro comparison with conivaptan, the program’s mixed V1a/V2-receptor antagonist standard

Bioorganic & Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Quality Control of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics