Ali, Amena published the artcileSynthesis and Biological Evaluations of N-(4-Substituted Phenyl)-7-Hydroxy-4-Methyl-2-Oxoquinoline-1(2H)-Carbothioamides, Quality Control of 3696-23-9, the publication is Polycyclic Aromatic Compounds, database is CAplus.
In continuance of search for new compounds authors report herein the expedient and optimized synthesis of a series of N-(4-substituted phenyl)-7-hydroxy-4-methyl-2-oxoquinoline-1(2H)-carbothioamides I (R = 4-Cl, 4-NO2, 4-Et, etc.) in good yields. The anticancer and antioxidant activities were determined as per the standard protocol. Nearly 5 dozens of cancer cell lines derived from nine different panels are used in the study and anticancer activity was calculated as growth percents (GPs) and percent growth inhibitions (%GIs). The mol. docking simulation against one of the potential targets i.e., epidermal growth factor receptor (EGFR) was done to find the putative approach of action of the title compds I. Compound I (R = 4-NO2) showed the most promising anticancer activity with higher sensitivity against UO-31, HOP-92, CAKI-1, LOX IMVI and T-47D with GPs of 66.65, 72.63, 85.80, 86.11, and 86.96 resp. The compd I (R = 4-NO2). exhibited antioxidant activity with an IC50 value of 15.21 +/= 1.52 μM. The mol. docking simulation showed an efficient binding of compd I (R = 4-NO2) against the activity site of EGFR with two H-bond interactions with the residues Gln791 and Thr854, a π-π stacking and a π-cationic interaction with the residue Phe856, while a salt bridge interaction with the residue Lys745.
Polycyclic Aromatic Compounds published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Quality Control of 3696-23-9.
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