Singh, Sarita published the artcileSynthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)benzopyran-4-one derivatives as anticancer agents, Synthetic Route of 4584-49-0, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(21), 5322-5327, database is CAplus and MEDLINE.
Different alkyl amide and alkyl amine derivatives of 7,8-dimethoxy-3-hydroxy-2-(4-methoxyphenyl)benzopyran-4-one were synthesized and evaluated for their anticancer activity against five different cancer cell lines using SRB assay. The most promising mol., 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one, was further analyzed for its effect on cell cycle and apoptosis of estrogen receptor pos. cancer cells (MCF-7 cells) which showed that 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one triggered apoptosis in MCF-7 cells and arrested cells population at sub-G0 (apoptotic) and G2M phase. In tubulin polymerization assay, 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one interfered with kinetics of tubulin polymerization
Bioorganic & Medicinal Chemistry Letters published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H5N3S, Synthetic Route of 4584-49-0.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics