Tenthorey, Paul A. published the artcileNew antiarrhythmic agents. 7. 2,3-Diaminopropionanilides, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1981), 24(9), 1059-63, database is CAplus and MEDLINE.
Ten 2,3-diaminopropionanilides I (R and R1 = Me, Et, Pr, etc.; R2,R3,R4, and R5 = H, OMe, OEt, etc.) were synthesized by acylation of mono- and disubstituted aniline derivatives with 2,3-dibromopropionyl chloride [18791-02-1] and subsequent amination with the appropriate secondary amines. I were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity. Several of the active agents had much higher antiarrhythmic potencies than lidocaine, but they were also toxic. Evaluation of the target compounds for local anesthetic activity in the form of sciatic nerve block in rats showed that most compounds had durations of block similar to that of lidocaine; none exhibited the long duration of block seen with etidocaine.
Journal of Medicinal Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C13H10N2S, Related Products of chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics