Keith, John M. published the artcileAryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate, HPLC of Formula: 61343-99-5, the main research area is aryl piperazinyl urea preparation FAAH inhibitor SAR analgesic; FAAH; FAAH-2; anandamide; enzyme; ethanolamides; urea.
A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003 (I), was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates.
ACS Medicinal Chemistry Letters published new progress about Analgesics. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, HPLC of Formula: 61343-99-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics