Madaiah, Malavalli published the artcileSynthesis and evaluation of 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives as potential anticonvulsants, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is oxotriazaspiroundecylmethylbenzonitrile preparation anticonvulsant.
New 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives were synthesized and their pharmacol. activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Four compounds showed significant and protective effect on seizure, when compared with the standard drug valproate. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug. From this study, it is quite apparent that there are at least three parameters for the activity of anticonvulsant drugs, i.e., a lipophilic domain, a hydrophobic center, and a two-electron donor. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics