Synthetic Route of 210532-25-5, A common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 25 mL round bottom flask was added 0.10 g (0.35 mmol, 1.0 eq) of JD 1001-002-10 solid, 3.2 mL THF, 0.13 g (1.05 mmol, 3.0 eq) DMAP, 0.22 g (1.05 mmol, 3.0 eq. 3,5-difluorobenzenesulfonyl chloride, the reaction was stirred at room temperature for 3 hours, and the reaction was completed by TLC (developing solvent: PE: EA = 1:1). The organic phase was washed twice with 0.5N aqueous hydrochloric acid and dried over anhydrous sodium sulfateIt was separated and purified by high pressure liquid phase (CH3CN: H2O = 60:40), and lyophilized to obtain 16 mg of JD1001-2064 product in a yield of 9%.
The synthetic route of 210532-25-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kunming Jida Pharmaceutical Co., Ltd.; Xiao Xuzhi; Zhang Poyong; Lu Faguan; Wang Zhipeng; Chen Mengran; Guo Kun; Zhou Rui; Zhang Yun; (28 pag.)CN109593061; (2019); A;,
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