Hideo, Endo; Tada, Masao; Katagiri, Ken published an article in 1965, the title of the article was Antitumor activity of phenazine derivatives against S 180 and C 63 in mice I.SDS of cas: 4569-86-2 And the article contains the following content:
Phenazine and 68 derivatives of phenazine were screened for their antitumor activity against Sarcoma 180 and Carcinoma 63, transplanted in mice. The ratio of the average weights of tumors in the treated and the controls, and the ratio of body weight changes in the 2 groups were recorded for each compound 2-Methoxyphenazine, 3,7-diamino-2-methylphenazine and 3-morpholino-1,2-benzophenazine at doses of 50 mg./kg.-body weight/day, brought down the tumor weight to less than half in the carcinoma infected mice and 3-acetamido-7-amino-5-phenylphenazonium chloride at the same dosage caused a similar effect in the sarcoma-infected animals. No correlation was observed between tumor weight change and the change in body weight in the treated animals. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).SDS of cas: 4569-86-2
3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas:4569-86-2) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. SDS of cas: 4569-86-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics