On April 30, 2020, Leppkes, Jakob; Hohmann, Thomas; Koksch, Beate published an article.Formula: C6H10Cl3NO The title of the article was Improved enantioselective gram scale synthesis route to N-Fmoc-protected monofluoroethylglycine. And the article contained the following:
Fluorine, as a substituent in amino acids, has found its way into peptide and protein engineering. The basis for the use of this valuable tool is the synthetic accessibility of various fluorinated amino acids as building blocks of peptides and proteins. In this context, we present a straightforward eight-step synthesis of N-Fmoc-L-monofluoroethylglycine (MfeGly) via homoserine (Hse) as intermediate and using various nucleophilic fluorination strategies. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO
The Article related to amino acid fluoroethylglycine fmoc protected enantioselective synthesis, glycine nucleophilic fluorination homoserine solvent effect, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Formula: C6H10Cl3NO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics