On May 1, 2020, Lowe, Robert A.; Taylor, Dale; Chibale, Kelly; Nelson, Adam; Marsden, Stephen P. published an article.Recommanded Product: 5034-06-0 The title of the article was Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds. And the article contained the following:
A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxypyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclization reactions of, and fusion of addnl. ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesized and evaluated in order to determine the biol. relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Recommanded Product: 5034-06-0
The Article related to tropane library synthesis hedgehog signaling inhibitor antimalarial, alkaloids, antimalarials, hedgehog signalling, molecular diversity, molecular scaffolds, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Recommanded Product: 5034-06-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics