Mohideen, Abbas Khaja; Mustaque, Kasim Mohammed; Meeran, Ismail Salim; Subramani, Annadurai; Ahamed, V. S. Jamal; Thajudeen, Habeebullah; Shabeer, Timiri Khudus published an article in 2022, the title of the article was Solvent-free synthesis, molecular simulation and cytotoxicity of 1,4-benzodiazepine-2,5-diones.SDS of cas: 89-77-0 And the article contains the following content:
The reaction of anthranilic acids with proline or pipecolic Me ester hydrochloride in presence of 1,1′-carbonyldiimidazole (CDI) on oil bath heating under solvent-free conditions afforded 1,4-benzodiazepine-2,5-dione (BZD) derivatives in moderate to good yields. Operational simplicity, absence of hazardous solvents, utility of an inexpensive coupling reagent (CDI) and mild reaction conditions are the significant advantages of this methodol. The cytotoxic activity of six BZDs were evaluated against HCT15 (Human Colon adenocarcinoma), SKMel2 (Human Skin Melanoma) and SKOV3 (Human Ovarian adenocarcinoma) cell lines. Compound I with p-Cl substitution showed moderate cytotoxicity against HCT15, SKMel2 and SKOV3 with IC50 values 37.04 +/- 1.13, 39.45 +/- 0.77 and 36.61 +/- 0.10μg/mL resp. The comprehensive anal. of the interaction between BZDs with receptor VEGFR-2 kinase, showed that compound I has higher mol. docking score with receptor. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).SDS of cas: 89-77-0
The Article related to benzodiazepine dione preparation green chem mol docking antitumor human, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.SDS of cas: 89-77-0
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