On May 15, 2008, Grewal, Gurmit; Hennessy, Edward; Kamhi, Victor; Li, Danyang; Lyne, Paul; Oza, Vibha; Saeh, Jamel Carlos; Su, Qibin; Yang, Bin published a patent.SDS of cas: 38939-88-7 The title of the patent was Preparation of heterocyclic sulfonamide compounds as Edg-1 antagonists useful in the treatment of cancer. And the patent contained the following:
The invention relates to chem. compounds of formula I (wherein ring A is carbocyclyl or heterocyclyl; n = 0-5; R1 is halo, nitro, cyano, etc.; R2 is C1-6alkyl, carbocyclyl, etc.; R3 is H, C1-6alkyl, etc.; or alternatively, R2 and R3 together may form part of C3-6carbocyclic ring; R4 is C1-6alkyl or carbocyclyl; Ring D is a 5-7 membered ring; R5 is a substituent on carbon and is halo, nitro, cyano, etc.; m is 0-5) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chem. compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man. Example compound II, prepared by reacting the appropriate sulfonyl chloride with [1-[1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]ethyl]amine, caused 100% inhibition of Edg-1 receptor activity at 3.70 μM in an in vitro cell based receptor activation assay. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7
The Article related to preparation heterocyclic sulfonamide edg1 receptor antagonist treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.SDS of cas: 38939-88-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics