On March 31, 2019, Szeto, Judy; Vu, Vi-Anh; Malerich, Jeremiah P.; Collins, Nathan published an article.Reference of trimethyloxosulphonium chloride The title of the article was Multi-step continuous flow synthesis of fluconazole. And the article contained the following:
The development of a flow chem. approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification The synthesis has been successfully demonstrated on a Vaportec com. flow chem. system. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Reference of trimethyloxosulphonium chloride
The Article related to fluconazole preparation continuous flow, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Reference of trimethyloxosulphonium chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics