On March 18, 2022, Rozema, Michael J.; Bhagavatula, Lakshmi; Christesen, Alan; Dunn, Travis B.; Ickes, Andrew; Kotecki, Brian J.; Marek, James C.; Moschetta, Eric; Morrill, Westin H.; Mulhern, Mathew; Rasmussen, Michael; Reynolds, Troy; Yu, Su published an article.Category: chlorides-buliding-blocks The title of the article was Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib. And the article contained the following:
Process development of a six-stage synthesis of upadacitinib, a JAK1 inhibitor, was described. It was highlighted by an enantioselective and diastereoselective hydrogenation of a tetrasubstituted olefin to set the two pyrrolidine stereocenters. Preparation of the main fragments and strategies to link them together, optimization of the imidazole cyclization and in-depth understanding of the formation of the urea moiety at the final stage were discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks
The Article related to upadacitinib preparation enantioselective diastereoselective, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics