On May 31, 2017, Liu, Li; Wang, Ting; Huang, Zhuyan; Li, Qin published a patent.Safety of 4-Chloro-2-fluorotoluene The title of the patent was Method for preparing 4-chloro-2-fluoro-phenylpropionic acid. And the patent contained the following:
The invention relates to the tech. field of chem. synthesis, especially a method for preparing 4-chloro-2-fluoro-phenylpropionic acid. The method uses low-cost and easily available 4-chloro-2-fluorotoluene as raw material to prepare the target product 4-chloro-2-fluoro-phenylpropionic acid through halogenation, nucleophilic substitution and hydrolytic decarboxylation, and the total yield of the target product can reach 74%. During the treatment process, the intermediate and the final product can be purified by the steps such as extraction, vacuum evaporation, vacuum filtration and recrystallization, which are easy to perform, and easily accomplish industrial production, compared with the column purification treatment. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Safety of 4-Chloro-2-fluorotoluene
The Article related to chlorofluorophenylpropionic acid preparation, Aliphatic Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of 4-Chloro-2-fluorotoluene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics