On December 17, 2020, Hong, Hao; Lu, Jiangping; Zhang, Enxuan; Liu, Zhiqing; Li, Chao published a patent.Synthetic Route of 452-75-5 The title of the patent was Continuous synthesis method for substituted benzoate organic matter. And the patent contained the following:
The present invention provides a continuous synthesis method for a substituted benzoate organic matter. Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5
The Article related to benzoate preparation oxidation carboxylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Synthetic Route of 452-75-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics