On November 30, 2020, Wang, Guangcheng; Liu, Wenjing; Tang, Juan; Ma, Xue; Gong, Zipeng; Huang, Yong; Li, Yongjun; Peng, Zhiyun published an article.Recommanded Product: 99-60-5 The title of the article was Design, synthesis and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors. And the article contained the following:
A series of (phenyl)(4-methoxynaphthalen-1-yl)methanones I [Ar = Ph, 4-FC6H4, naphthalen-2-yl, etc.] was designed, synthesized via reaction of 1-methoxynaphthalene with aromatic carboxylic acids and evaluated for their antiproliferative activity against human breast cancer cell line (MCF-7). Most of the tested derivatives I showed good to moderate cytotoxicity against MCF-7 cell line, among which compound I [Ar = 3-OH-4-MeOC6H3] (IC50 = 1.47 ± 0.14μM) was found to be the most active compound, which was more active than the standard drug cisplatin (IC50 = 15.24 ± 1.27μM). In vitro tubulin polymerization inhibition assay, EBI competition assay, cell cycle anal. and cell apoptosis assay identified that compound I [Ar = 3-OH-4-MeOC6H3] was a new tubulin polymerization inhibitor by targeting the colchicine binding site. Mol. docking study showed that compound I [Ar = 3-OH-4-MeOC6H3] possessed high binding affinities with the colchicine binding site of tubulin through hydrogen bond, cation-π, and hydrophobic interaction. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5
The Article related to phenyl methoxynaphthalenyl methanone preparation sar tubulin polymerization antitumor human, anticancer activity, benzophenone, naphthalene, tubulin polymerization inhibitors and other aspects.Recommanded Product: 99-60-5
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