On August 13, 2009, Ritter, Tobias; Furuya, Takeru; Kaiser, Hanns M. published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was System for fluorinating organic compounds using palladium complexes and fluorinating agents. And the patent contained the following:
Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes of formula I. Also described herein are compositions and kits containing compounds and palladium complexes described herein. Palladium complexes of formula I wherein Pd has valence +2; R11 and R12 are independently (un)substituted aliphatic, (un)substituted heteroaliph., (un)substituted aryl, etc.; when W is C and CRd, Z is a bond, O, S, (un)substituted methylene, (un)substituted ethenylene, N- joined via L to R11, etc.; and L is CO, CO2, SO2, etc.; when W is N and NH and derivatives, Z is a bond, (un)substituted methylene, (un)substituted ethenylene, etc.; Rd is H, (un)substituted aliphatic, (un)substituted heteroaliph., etc.; R1, R2, R3 and R4 are independently (un)substituted aliphatic, (un)substituted heteroaliph., (un)substituted aryl; R1R2 R2R3, and R3R4 are independently taken together to form (un)substituted 5- to 7-membered aryl, heteroaryl, heterocyclic and carbocyclic ring; dashed bon is single and double bond; provided that at least one of R11 and R12 is neg. charged moiety or the complex further comprises of a neg. charged counter ion; are claimed. Fluorobenzene was prepared by transmetalation of II with phenylboronic acid, the resulting phenylpalladium sulfamidate complex underwent electrophilic fluorination to give fluorobenzene. The fluorinated organic compounds may be useful as imaging agents. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene
The Article related to arylboronic acid palladium acetate sulfamidate complex transmetalation, arylpalladium sulfamidate preparation electrophilic fluorination, fluoro arene preparation imaging agent and other aspects.Reference of 4-Chloro-2-fluorotoluene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics