On March 20, 2020, Soni, Arvind S.; Vacariu, Condarache M.; Chen, Jeff Y.; Tanner, Martin E. published an article.Quality Control of tert-Butyl trichloroacetimidate The title of the article was Synthesis of a meso-oxa-diaminopimelic acid containing peptidoglycan pentapeptide and coupling to the GlcNAc-anhydro-MurNAc disaccharide. And the article contained the following:
The syntheses of peptidoglycan (PG)-derived peptides containing meso-diaminopimelic acid (meso-Dap) are typically quite lengthy due to the need to prepare orthogonally protected meso-Dap. In this work, the preparation of the PG pentapeptide containing the isosteric analog meso-oxa-Dap is described. The synthesis relies on the ring opening of a peptide embedded aziridine via the attack of a serine residue. The pentapeptide was attached to a GlcNAc-anhydro-MurNAc disaccharide, to produce a putative substrate for the AmpG pore protein. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Quality Control of tert-Butyl trichloroacetimidate
The Article related to meso oxadiaminopimelic acid peptidoglycan pentapeptide synthesis coupling disaccharide, peptide cyclization coupling aziridine peptide ring opening heine reaction, ampg pore protein substrate and other aspects.Quality Control of tert-Butyl trichloroacetimidate
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