On December 1, 2019, Onder, Seda; Biberoglu, Kevser; Tacal, Ozden published an article.Computed Properties of 4569-86-2 The title of the article was The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. And the article contained the following:
Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic mols. with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibitory effects of a synthetic phenazine dye, methylene violet 3RAX (also known as di-Et safranine) on human erythrocyte AChE and human plasma BChE were tested and also its inhibitory mechanisms for both enzymes were studied in detail. Kinetic anal. showed that methylene violet 3RAX acts as a hyperbolic noncompetitive inhibitor of AChE with Ki value of 1.58 ± 0.36μM; α = 1; β = 0.12 ± 0.0003. On the other hand, it caused linear competitive inhibition of BChE with Ki value of 0.51 ± 0.006μM; α = ∞. In conclusion, methylene violet 3RAX which is a highly effective inhibitor of both human AChE and human BChE with Ki values in low micromolar range may be a promising candidate for the treatment of Alzheimer’s disease. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Computed Properties of 4569-86-2
The Article related to human erythrocyte plasma acetylcholinesterase butyrylcholinesterase methylene violet inhibition kinetics, acetylcholinesterase, butyrylcholinesterase, cholinesterase inhibition, methylene violet 3rax and other aspects.Computed Properties of 4569-86-2
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics