On September 2, 1987, Fukuoka, Shinsuke published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was A process for preparation of aryl fluorinated aromatic carboxylates by carbonylation of fluorinated aryl halides in the presence of phenols. And the patent contained the following:
The title compounds, useful as intermediates for heat-resistant polymers, agrochems., and pharmaceuticals, are prepared A mixture of p-IC6H4F 22.2, PhOH 11.3, Bu3N 22.2, and Ni(acac)2 0.77 g was autoclaved under CO at 50 kg/cm2 and 200-220° for 2 h to give 95% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene
The Article related to fluoroarom carboxylate aryl ester preparation, fluorobenzoate phenyl ester preparation, pharmaceutical agrochem intermediate aryl fluoroarom carboxylate, heat resistant polymer intermediate fluoroarycarboxylate ester, carbonylation fluoroaryl halide and other aspects.Reference of 4-Chloro-2-fluorotoluene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics