Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Safety of 4-Fluorobenzene-1-sulfonyl chloride.
Yu, Yingjie;Liu, Aiyao;He, Jingrui;Wang, Chengting;Mei, Haibo;Han, Jianlin research published 《 Visible-light-irradiated tandem sulfonylation/cyclization of indole tethered alkenes for the synthesis of tetrahydrocarbazoles》, the research content is summarized as follows. A visible-light-mediated reaction of indole derivatives I (R = H, Br, F, Me; R1 = H, Me, MeO, Br, Cl, F; R2 = H, F, Br, Cl; R3 = H, Me; R4 = Et, i-Pr; R5 = H, Boc; R6 = H, Me) employing arylsulfonyl chlorides R7S(O)2Cl (R7 = 2,4,6-trimethylphenyl, 3-bromophenyl, biphenyl-4-yl, etc.) as sulfonyl surrogates has been developed, which proceeds via the sequence of reduction of sulfonyl chloride, sulfonylation, and intramol. cyclization. This mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized II tetrahydrocarbazoles in good yields. This reaction is also suitable for gram-scale synthesis, which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Safety of 4-Fluorobenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics