Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. HPLC of Formula: 104-86-9.
Satish, Sohal;Chitral, Rohan;Kori, Amitkumar;Sharma, Basantkumar;Puttur, Jayashree;Khan, Afreen A.;Desle, Deepali;Raikuvar, Kavita;Korkegian, Aaron;Martis, Elvis A. F.;Iyer, Krishna R.;Coutinho, Evans C.;Parish, Tanya;Nandan, Santosh research published 《 Design, synthesis and SAR of antitubercular benzylpiperazine ureas》, the research content is summarized as follows. N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos mols. with a Ph ring led to mol. I with an MIC of 1μM against Mtb H37Rv, low cellular toxicity (HepG2 IC50 ∼ 80μM), good DMPK properties and specificity for Mtb. With the aim of delineating the SAR associated with compound I, fifty-five analogs were synthesized and screened against Mtb. The SAR suggested that the piperazine ring, benzyl urea and piperonyl moieties were essential signatures of this series. Active compounds in this series were metabolically stable, have low cellular toxicity and were valuable leads for optimization. Mol. docking suggests these mols. occupy the Q0 site of QcrB like Q203.
HPLC of Formula: 104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics