Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: 4-Fluorobenzene-1-sulfonyl chloride.
Lei, Siyu;Pan, Tao;Wang, Maorong;Zhang, Yuexia research published 《 Fe-catalyzed reduction of aldimines with HBpin》, the research content is summarized as follows. An efficient and workable method for the reduction of imines via hydroboration with HBpin was developed. The low cost and non-toxic Fe exhibited high catalytic activity to this hydroboration. A large range of aldimines comprising diverse aryl groups, alkyl groups and heterocycles proceeded the hydroboration well to yield secondary amines RCH2NHR1 = [R = Ph, 2-FC6H4, 2-thienyl, etc.; R1 = t-Bu, Ph, Bn, etc.] in good to excellent yields. Kinetic mechanistic studies indicated the importance of Fe in transformation of HBpin into an active species. The preparation of several com. available pharmaceuticals by means of this strategy highlighted its potential application in medicinal chem.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Name: 4-Fluorobenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics