On September 29, 1993, Axelsson, Oskar; Peters, Dan; Nielsen, Elsebet Ostergaard; Christophersen, Palle published a patent.Electric Literature of 38939-88-7 The title of the patent was Imidazole compounds, their preparation and use. And the patent contained the following:
The title compounds, particularly the benzimidazole derivatives and 3H-imidazo[4,5-b]pyridine derivatives, I (X, Y = carbon, nitrogen; R12, R13 = alkyl; R4-R7 = H, halo, amino, cyano, etc.) and their uses for the treatment of diseases responsive to blocking of calcium channels of the central nervous system are claimed. Such diseases include degenerative changes associated with stroke, ischemia, migraine, psychosis, Parkinson’s disease, depression, epilepsy, or convulsive disorders. For example, 1-(4-iodophenyl)-4-fluorobenzimidazole (II) had an in vitro activity as L-type calcium channel blocker. Other I were tested for activity as N-type and P-type calcium channel blockers. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7
The Article related to ischemia benzimidazole imidaopyridine phenyl, migraine benzimidazole imidaopyridine phenyl, antipsychotic benzimidazole imidaopyridine phenyl, antidepressant benzimidazole imidaopyridine phenyl, antiepileptic benzimidazole imidaopyridine phenyl, anticonvulsant benzimidazole imidaopyridine phenyl, calcium channel blocker benzimidazole imidaopyridine and other aspects.Electric Literature of 38939-88-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics