Adding a certain compound to certain chemical reactions, such as: 870-24-6, name is 2-Chloroethanamine hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870-24-6, Quality Control of 2-Chloroethanamine hydrochloride
2-Chloroethylamine hydrochloride (E-5 A) 70% aqueous solution (1 mol) and K2CO3 (1.2 mol) were dissolved in distilled water (4 Liter). TsCl (1 mol) was added slowly with stirring. The reaction mixture was stirred at room temperature for about 24 h. The pH of the reaction mixture was adjusted to 9 by slow addition of 4 M KOH solution and the mixture kept stirring until TLC indicated all the TsCl were quenched. The resulting precipitate was collected by using suction filtration, washed with distilled water, and dried in vacuo (220 g, 95% yield), mp: 77-78 0C. 1H NMR (CDCl3): delta 2.4 (3 H, s), 3.28 (2 H, q), 3.52 (2 H, t), 5.2 ( I H, s), 7.4 (2 H, dd), 7.9 (2 H, dd).
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Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; WO2008/63721; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics