Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4152-90-3, name is (3-Chlorophenyl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 4152-90-3
A solution of 5-chloro-jV-cyclohexylpyrazolo[ 1 ,5-alpha]pyrimidine-3-carboxamide(28 mg, 0.09 rnM, 1.0 equiv), 3-chlorobenzylamine (28 mg, 0.18 rnM, 2.0 equiv), N5N- diisopropylethylamine (26 mg, 0.18 rnM, 2.0 equiv) and 2 rnL of ethanol were microwaved at 120 0C for 10 minutes. TLC (95:5 dichloromethane methanol) showed reaction complete. The reaction mixture was cooled, the crystalline product collected by filtration, washed with cold ethanol and air dried to yield 29.7 mg (77percent) of 5-(3-chlorobenzylamino)-7V- cyclohexylpyrazolo[l,5-alpha]pyrimidine-3-carboxamide. LCMS (ESI) m+H = 384.2; 1H NMR (400 MHz, OMSO-d) delta: 8.61 (overlapping d and t, 2 H), 8.06 (s, 1 H), 7.60 (d, 1 H), 7.4- 7.25 (m, 4 H), 6.49 (d, 1 H), 3.70 (m, 1 H), 1.75-1.5 (m, 5 H), 1.4-0.8 (m, 5 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GENENTECH, INC.; BLANEY, Jeffrey; GIBBONS, Paul A.; HANAN, Emily; LYSSIKATOS, Joseph P.; MAGNUSON, Steven R.; PASTOR, Richard; RAWSON, Thomas E.; ZHOU, Aihe; ZHU, Bing-Yan; WO2010/51549; (2010); A1;,
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