Safety of 4-Chlorobenzenesulfonyl chlorideIn 2019 ,《Direct coupling of haloquinolines and sulfonyl chlorides leading to sulfonylated quinolines in water》 was published in Tetrahedron Letters. The article was written by Bao, Pengli; Wang, Leilei; Liu, Qishun; Yang, Daoshan; Wang, Hua; Zhao, Xiaohui; Yue, Huilan; Wei, Wei. The article contains the following contents:
A simple and efficient method has been developed for construction of sulfonylated quinolines via coupling of haloquinolines and sulfonyl chlorides in water [e.g., 2-chloroquinoline + tosyl chloride → 2-tosylquinoline (93%, 89% isolated) using Zn powder as reductant at 80° in water]. The present methodol. provides an attractive approach to various sulfonylated quinolines in moderate to good yields with favorable functional group tolerance, which has the advantages of operation simplicity, readily available starting materials, excellent regioselectivity, scale-up synthesis, and organic solvent-free conditions. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Safety of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics