Weiss, Alexander K. H.; Wurzer, Richard; Klapec, Patrycia; Eder, Manuel Philip; Loeffler, Johannes R.; von Grafenstein, Susanne; Monteleone, Stefania; Liedl, Klaus R.; Jansen-Duerr, Pidder; Gstach, Hubert published an article in 2021. The article was titled 《Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)》, and you may find the article in Molecules.SDS of cas: 5781-53-3 The information in the text is summarized as follows:
FAH domain containing protein 1 (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle. Guided by a high-resolution X-ray structure of FAHD1 liganded by oxalate, the enzymic mechanism of substrate processing is analyzed in detail. Taking the chem. features of the FAHD1 substrate oxaloacetate into account, the potential inhibitor structures are deduced. The synthesis of drug-like scaffolds afforded first-generation FAHD1-inhibitors with activities in the low micromolar IC50 range. The investigations disclosed structures competing with the substrate for binding to the metal cofactor, as well as scaffolds, which may have a novel binding mode to FAHD1. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.SDS of cas: 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics