Electric Literature of C4H3ClO2S2In 2021 ,《Visible-Light-Induced 1,4-Hydroxysulfonylation of Vinyl Enynes with Sulfonyl Chlorides: The Bridge of Chloride Linking Water and Enynes》 was published in Organic Letters. The article was written by Zhang, Cheng-Yun; Zhu, Jie; Cui, Su-Hang; Xie, Xiao-Yu; Wang, Xiao-Dong; Wu, Lei. The article contains the following contents:
A novel visible-light-induced 1,4-hydroxysulfonylation of vinyl enynes I (R1 = R2 = Ph, 4-MeC6H4, 4-ClC6H4, 4-FC6H4; R1 = Ph, R2 = Me; R3 = H, n-hexyl, Ph, 4-MeOC6H4, 1-naphthyl, 3-pyridinyl, 3-thienyl, etc.) with sulfonyl chlorides R4SO2Cl (R4 = Et, Me2N, Ph, 4-MeC6H4, 2-thienyl, etc.) has been established, providing a highly efficient protocol to access multisubstituted sulfonyl allenic alcs. II. Control experiments and mechanistic studies disclose that the target products result from sequential reactions of hydroxyl and tosyl radicals, among which chloride anion plays a key role to generate the requisite hydroxyl radical, thus bridging water and enynes. Moreover, the vinyl pendant is believed to decisively affect the site-selectivity of hydroxyl radical.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2) was used in this study.
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics