《Synthesis, characterization and biological activities of sulfonamide tagged 1,2,3-triazoles》 was published in Synthetic Communications in 2020. These research results belong to Kaushik, C. P.; Chahal, Manisha; Luxmi, Raj; Kumar, Devinder; Kumar, Ashwani; Kumar, Mukesh; Singh, Dharmendra. Recommanded Product: 4-Chlorobenzenesulfonyl chloride The article mentions the following:
The synthesis of a series of sulfonamide containing 1,4-disubstituted 1,2,3-triazoles I [R1 = H, F, Cl, Br; R2 = Ph, 3-pyridinyl, 1-naphthyl, etc.] through click reaction of terminal alkynes with aromatic azides was reported. The synthesized triazoles I were characterized by FTIR, 1H NMR,13C NMR and HRMS techniques. Further, the structures of synthesized compounds I [R1 = Cl, R2 = 4-chlorophenyl] (CCDC 1954932) and I [R1 = Br, R2 = 4-chlorophenyl] (CCDC 1954931) were also confirmed by X-ray crystallog. The synthesized triazoles I were evaluated for in-vitro antibacterial activity against S. aureus, B.subtilis, E. coli and K. pneumoniae by serial dilution method. Among the series, compounds I [R1 = Br, R2 = 4-bromophenyl, 1-naphthyl] (MIC = 0.025μM/mL) and (MIC = 0.027μM/mL) resp. exhibited the appreciable antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Further, the mol. docking studies of above potent analogs with dihydropteroate synthase was performed to have an insight for binding interactions. Synthesized mols. I were also explored for antioxidant activity, reflecting compound I [R1 = F, R2 = 4-chlorophenyl] as better radical scavenging agent with IC50 value of 1.96μM/mL. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Recommanded Product: 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics