Formula: C43H72Cl2P2RuIn 2020 ,《Helix stabilization by stapled N-capping box》 was published in Bioorganic Chemistry. The article was written by Pham, Thanh K.; Kim, Young-Woo. The article contains the following contents:
The N-capping box is a distinct helix-stabilizing motif frequently found in proteins. In this study, we examined a ruthenium-mediated intramol. backbone to side chain macrocyclization as a rigidified mimicry of the N-capping box. Exptl. data indicate that the 15-membered macrocycle formed by a hept-4-enoyl staple, which directly tethers the α-amino group of N1 residue and the α-carbon of N3 residue, is highly effective in stabilizing helical structures of short peptides. In addition to this study using Benzylidenebis(tricyclohexylphosphine)dichlororuthenium, there are many other studies that have used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Formula: C43H72Cl2P2Ru) was used in this study.
Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Formula: C43H72Cl2P2Ru
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics