Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article in 2022. The article was titled 《Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles》, and you may find the article in Chinese Chemical Letters.COA of Formula: C7H6BrCl The information in the text is summarized as follows:
The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics