《Synthesis, evaluation of thymidine phosphorylase and angiogenic inhibitory potential of ciprofloxacin analogues: Repositioning of ciprofloxacin from antibiotic to future anticancer drugs》 was published in Bioorganic Chemistry in 2020. These research results belong to Shahzad, Sohail Anjum; Sarfraz, Ayesha; Yar, Muhammad; Khan, Zulfiqar Ali; Naqvi, Syed Ali Raza; Naz, Sadia; Khan, Nazeer Ahmad; Farooq, Umar; Batool, Razia; Ali, Muhammad. Computed Properties of C6H4Cl2O2S The article mentions the following:
Discovery of potent inhibitors of thymidine phosphorylase (TP) can offer appropriate approach in cancer treatment. A series of ciprofloxacin derivatives has been synthesized and inhibitory activity of these ciprofloxacin derivatives against thymidine phosphorylase enzyme was assessed. Out of these twelve analogs of ciprofloxacin, nine analogs exhibited good inhibitory activity against thymidine phosphorylase. Inhibitory activity as presented by their IC50 values was found in the range of 39.71 ± 1.13 to 161.89 ± 0.95μM. The 7-deazaxanthine was used as a standard inhibitor with IC50 = 37.82 ± 0.93μM. Furthermore, the chick chorionic allantoic membrane (CAM) assay was used to investigate anti-angiogenic activity of the most active ciprofloxacin-based inhibitor compound I. To enlighten the important binding interactions of ciprofloxacin derivatives with target enzyme, the structure activity relationship and mol. docking studies of chosen ciprofloxacin analogs was discussed. Docking studies revealed key π-π stacking, π-cation and hydrogen bonding interactions of ciprofloxacin analogs with active site residues of thymidine phosphorylase enzyme. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Computed Properties of C6H4Cl2O2S Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics