In 2022,Korkmaz, Adem; Bursal, Ercan published an article in Journal of Molecular Structure. The title of the article was 《Benzothiazole sulfonate derivatives bearing azomethine: Synthesis, characterization, enzyme inhibition and molecular docking study》.Name: 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:
Enzyme inhibition is one of the most applied ways to find new diagnostic facilities for the prevention and treatment of many health problems. For example, tyrosinase and pancreatic lipase inhibition have been used for the treatment of skin pigmentation problems and obesity, resp. This study mainly focused on evaluating inhibition of tyrosinase and pancreatic lipase by newly synthesized sulfonate derivatives I [R = 2,4,6-Me3C6H2, 2-naphthyl, 4-BrC6H4, etc.]. The structural characterizations of the compounds were performed by 1H NMR, 13C NMR and HR-MS analyses. According to the in-vitro enzyme inhibition methods, compound I [R = 4-FC6H4] had the highest tyrosinase inhibitory activity (46.9 ± 3.6μM IC50 value). On the other hand, effective pancreatic lipase inhibitory activities of I [R = 4-MeOC6H4, 4-FC6H4, 4-MeC6H4] were determined from their low IC50 values 58.3 ± 6.7μM, 59.5 ± 13.8μM and 64.8 ± 6.3μM, resp. Mol. docking studies were also conducted with tyrosinase and pancreatic lipase enzymes sep. Finally, the ADME studies were carried out to determine the pharmacokinetics, drug similarities and medicinal properties of the target compounds4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Name: 4-Chlorobenzenesulfonyl chloride Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics