Computed Properties of C6H6BFO2In 2021 ,《[3+2+1] Pyridine Skeleton Synthesis Using Acetonitrile as C4N1 Units and Solvent》 appeared in Journal of Organic Chemistry. The author of the article were Bai, Chaolumen; Guo, Huifang; Liu, Xin; Liu, Dan; Sun, Zhaorigetu; Bao, Agula; Baiyin, Menghe; Muschin, Tegshi; Bao, Yong-Sheng. The article conveys some information:
The first [3+2+1] methodol. for pyridine skeleton I (R = 4-isopropylphenyl, 3-fluorophenyl, 2-naphthyl, etc.; R1 = Me, Ph, furan-2-yl, etc.) synthesis via cascade carbopalladation/cyclization of acetonitrile, arylboronic acids RB(OH)2, and aldehydes R1CHO was developed. This reaction proceeds via six step tandem reaction sequences involving the carbopalladation reaction of acetonitrile, a nucleophilic addition, a condensation, an intramol. Michael addition, cyclization, and aromatization. Delightfully, both palladium acetate and supported palladium nanoparticles catalyzed this reaction with similar catalytic performance. The characterization results of the fresh and used supported palladium nanoparticle catalysts indicated that the reaction might be performed via a Pd(0)/Pd(II) catalytic cycle that began with Pd(0). Furthermore, the products showed good fluorescence characteristics. The green homogeneous/heterogeneous catalytic methodologies pave a new way for constructing the pyridine skeleton. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics