《Design, synthesis and anticancer evaluation of 1,2,4-thiadiazole linked benzoxazole-quinazoline derivatives》 was published in Chemical Data Collections in 2020. These research results belong to Perupogu, Neerada; Krishna, Ch. Murali; Ramachandran, Dittakavi. Application of 16629-19-9 The article mentions the following:
The authors designed and synthesized a series of 1,2,4-thiadiazole-incorporated benzoxazole-quinazoline derivatives I [Ar = 2-thiophenyl, 4-MeC6H4, 3,5-Cl2C6H3, etc.] and screened them for anticancer activity against human cancer cell lines that included MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer). The clin. agent etoposide was chosen as the pos. control. Among the tested compounds, I [Ar = 5-methylisoxazol-4-yl] showed efficient anticancer activities against the four cancer cell lines. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics