《Access to galectin-3 inhibitors from chemoenzymic synthons》 was written by Dussouy, Christophe; Teletchea, Stephane; Lambert, Annie; Charlier, Cathy; Botez, Iuliana; Ceuninck, Frederic De; Grandjean, Cyrille. Quality Control of Methyl 2-chloro-2-oxoacetate And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:
Chemoenzymic strategies are useful for providing both regio- and stereoselective access to bioactive oligosaccharides. We show herein that a glycosynthase mutant of a Thermus thermophilus α-glycosidase can react with unnatural glycosides such as 6-azido-6-deoxy-D-glucose/glucosamine to lead to β-D-galactopyranosyl-(1→3)-D-glucopyranoside or β-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-D-glucopyranoside derivatives bearing a unique azide function. Taking advantage of the orthogonality between the azide and the hydroxyl functional groups, the former was next selectively reacted to give rise to a library of galectin-3 inhibitors. Combining enzyme substrate promiscuity and bioorthogonality thus appears as a powerful strategy to rapidly access to sugar-based ligands. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Methyl 2-chloro-2-oxoacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics