Wan, Hai-Lan; Guan, Zhi; He, Yan-Hong published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Electrochemically Promoted Bifunctionalization of Alkynes for the Synthesis of β-Keto Sulfones》.Name: Thiophene-2-sulfonyl chloride The article contains the following contents:
An electrochem. oxidative difunctionalization of internal and terminal alkynes with sulfonyl hydrazides for the synthesis of β-keto sulfones has been achieved. The reaction involves the addition of sulfonyl radicals to alkynes, and the resulting alkenyl radicals are oxidized to alkenyl cations, which are then nucleophilically attacked by H2O, followed by tautomerization to form β-keto sulfones. The method is green and sustainable as it is catalyst-free, oxidant-free, and additive-free. The new C-O and C-S bonds can be constructed in one-pot to directly access β-keto sulfone derivatives In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride) was used in this study.
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics