In 2022,Chang, Xiaoqiang; Chen, Xingyu; Lu, Sixian; Zhao, Yifan; Ma, Yue; Zhang, Dong; Yang, Lan; Sun, Peng published an article in Advanced Synthesis & Catalysis. The title of the article was 《Electrochemical [3+2] Cycloaddition of Anilines and 1,3-Dicarbonyl Compounds: Construction of Multisubstituted Indoles》.Category: chlorides-buliding-blocks The author mentioned the following in the article:
Herein, the intermol. electro-oxidative cycloaddition of anilines and com. available 1,3-dicarbonyl compds was reported. This method provided an alternative route for the synthesis of a broad range of multisubstituted indoles I [R1 = H, 5-EtO, 6-Cl,5-MeO, etc.; R2 = Ts, benzenesulfonyl, ethylsulfonyl, etc.; R3 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.] without a transition-metal catalyst or external chem. oxidant. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks) was used in this study.
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics