In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15205-15-9 as follows. Computed Properties of C7H7ClFN
The above intermediate (0.14 mmol, 35 mg) was dissolved in dimethyl sulfoxide (DMSO), to which were added HOBt (0.35 mmol, 49.43 mg), EDCl ¡¤ HCl (0.35 mmol, 68.42 mg), DIEA (0.56 mmol, 73.79 mg). After stirring at room temperature for 15 minutes, (0.14 mmol, 22.82 mg) (CAS: 68220-26-8, Bide, Shanghai) was added. The reaction was carried out at room temperature for 5 hours. The reaction system was extracted with water/ethyl acetate (3 x 15 mL), then the organic phase was washed with saturated sodium chloride solution, dried with anhydrous sodium sulfate, concentrated, purified by reverse phase preparative HPLC (using 0.35% trifluoroacetic acid-containing aqueous solution and methanol as mobile phase), and vacuum concentrated to obtain compound I-a-1 (12.1 mg, 22%).
According to the analysis of related databases, 15205-15-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xiamen University; DENG, Xianming; WANG, Hongrui; ZENG, Taoling; ZHANG, Ting; JIANG, Tingting; (181 pag.)EP3626718; (2020); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics