Kaden, Felix; Nowotni, Susanne; Hofner, Franziska; Lorenz, Melanie; Barthel, Andre; Jager, Anne; Hennersdorf, Felix; Weigand, Jan J.; Metz, Peter published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Asymmetric Total Synthesis of (-)-Dehydrocostus Lactone by Domino Metathesis》.SDS of cas: 172222-30-9 The article contains the following contents:
An efficient total synthesis of the sesquiterpenoid (-)-dehydrocostus lactone (I) is reported. Our earlier approach by a domino enediyne metathesis was extended by a domino dienyne metathesis strategy to give access to suitably functionalized hydroazulene cores. Highly stereoselective asym. anti aldol reactions provided the enantiopure substrates for this key step of our synthesis. Multiple hydroboration/oxidation of the resulting hydroazulenes set up three out of four stereogenic centers in a single step. First, oxidation to give a diketo-γ-lactone enabled an enantioselective formal synthesis of the target guaianolide. Subsequently, the final steps of this approach were improved by using a double carbonyl olefination at the stage of a masked γ-butyrolactone, which completed the synthesis in a much more efficient way. In the part of experimental materials, we found many familiar compounds, such as Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9SDS of cas: 172222-30-9)
Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.SDS of cas: 172222-30-9
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