Giorgianni, Giuliana; Nori, Valeria; Baschieri, Andrea; Palombi, Laura; Carlone, Armando published the artcile< Organocatalyzed Michael addition to nitroalkenes via masked acetaldehyde>, Reference of 5153-70-8, the main research area is nitroaldehyde preparation enantioselective; acetaldehyde nitroalkene Michael addition organocatalyst.
A novel and safe reaction protocol for the enantioselective enamine-catalyzed addition of acetaldehyde to nitroalkenes R1CH=CHNO2 (R1 = Bu, 4-chloropheny, 2-phenylethyl, etc.) is presented; this protocol makes use of a safe acetaldehyde precursor to access important intermediates R/S-R1CH(CH2C(O)H)CH2NO2 to Active Pharmaceutical Ingredients (APIs), and allows the use of fewer equivalent of acetaldehyde and lower catalyst loadings. The reaction developed proved to be suitable to be performed on gram-scale and to produce key intermediates, such as (R)-5-methyl-3-(nitromethyl)hexanal for the synthesis of pharmacol. active compounds such as pregabalin.
Catalysts published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (nitro). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Reference of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics