Yasunaga, Katsuaki; Kiyonari, Akiko; Nakagawa, Munehiro; Yoshikawa, Kunie published the artcile< Investigation into the ability of the Salmonella umu test to detect DNA damage using antitumor drugs>, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is antitumor genotoxicity Salmonella umu gene.
In order to examine the ability of the umu test detecting system, 18 antitumor drugs were tested using the Salmonella umu test. The tested antitumor drugs were selected so as to produce different biochem. actions, and they were classified into three categories; five agents of group I (antimetabolites), eight agents of group II (alkylating agents), and five agents of group III (antibiotics). The results showed that all antimetabolites, all alkylating agents, and three of the antibiotics had pos. responses, but the antibiotics aclarubicin (ACR) and chromomycin A3 (CHR) had neg. responses. Both antibiotics that gave neg. responses were anthracyclines, but daunomycin (DNR), which was one of the anthracyclines, had a pos. result in the umu test. These results suggest that it is possible for the umu test to detect genotoxicity of chems. regardless of the types of DNA damage (inhibition of DNA synthesis relative enzyme, DNA base alkylating, DNA strand-break, and DNA adduct), but difficult for it to detect genotoxicity of any anthracyclines.
Toxicology in Vitro published new progress about Anthracyclines Role: ADV (Adverse Effect, Including Toxicity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Safety of 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.
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