Chekan, Jonathan R.; Lee, Ga Young; El Gamal, Abrahim; Purdy, Trevor N.; Houk, K. N.; Moore, Bradley S. published the artcile< Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase>, Formula: C4H4ClNO2, the main research area is crystal structure tetrabromopyrrole debrominase dehalogenation thyroid deiodinase.
Enzymic dehalogenation is an important and well-studied biol. process in both the detoxification and catabolism of small mols., many of which are anthropogenic in origin. However, dedicated dehalogenation reactions that replace a halogen atom with a hydrogen are rare in the biosynthesis of natural products. In fact, the debrominase Bmp8 is the only known example. It catalyzes the reductive debromination of the coral settlement cue and the potential human toxin 2,3,4,5-tetrabromopyrrole as part of the biosynthesis of the antibiotic pentabromopseudilin. Using a combination of protein crystallog., mutagenesis, and computational modeling, we propose a catalytic mechanism for Bmp8 that is reminiscent of that catalyzed by human deiodinases in the maintenance of thyroid hormones. The identification of the key catalytic residues enabled us to recognize divergent functional homologs of Bmp8. Characterization of one of these homologs demonstrated its debromination activity even though it is found in a completely distinct genomic context. This observation suggests that addnl. enzymes outside those associated with the tetrabromopyrrole biosynthetic pathway may be able to alter the lifetime of this compound in the environment.
Biochemistry published new progress about Crystal structure. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Formula: C4H4ClNO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics