Jeon, Hyojin; Ko, Soo-Byung; Lee, Sunwoo published the artcile< Palladium-catalyzed decarboxylative gem-selective addition of alkynoic acids to terminal alkynes>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is gem enyne preparation regioselective DFT study; alkynoic acid terminal alkyne decarboxylative addition palladium catalyst.
The regioselective palladium-catalyzed decarboxylative head-to-tail addition of alkynoic acid derivatives to terminal alkynes furnished gem-1,3-enynes. Both aryl- and alkyl-substituted alkynoic acids showed favorable reactivity and high selectivity. The proposed method provided good yields and showed broad functional group tolerance. In addition, the reaction of alkynoic acids with propiolic acid provided the corresponding gem-1,3-enynes via double decarboxylation. This is the first example of propiolic acid being employed as an acetylene surrogate for the formation of gem-1,3-enynes. D. functional theory calculations were conducted to rationalize the high selectivity observed in the formation of head-to-tail addition products.
Organic Chemistry Frontiers published new progress about Addition reaction (decarboxylative). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics