Gormemis, Ahmet E.; Ha, Tal Soo; Im, Isak; Jung, Kwan-Young; Lee, Ju Yeon; Park, Chul-Seung; Kim, Yong-Chul published the artcile< Benzofuroindole analogues as potent BKCa channel openers>, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate, the main research area is arylhydrazine benzofuranone condensation; arylhydrazone benzofuranone preparation Fischer cyclization acid catalyst; benzofuranone arylhydrazone preparation Fischer cyclization microwave irradiation acid catalyst; benzofuroindole preparation potassium channel opener; structure activity relationship benzofuroindole potassium channel opener.
New, potent, large-conductance, calcium-activated potassium-channel (BKCa) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R1 = H, Br; R2 = H, CF3, OCH3, Cl; R3 = H, COOH, COOCH3, Cl, OCH3, CF3; R4 = H, Cl, F; R5 = H, Cl, CF3; R6 = H, Cl, F, CF3) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BKCa-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R1 = R4 = R5 = H; R2 = CF3; R3 = COOH, R6 = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.
ChemBioChem published new progress about Fischer indole synthesis. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics